In The Lost Weekend, a film that won 4 Oscars, we accompany the failed writer Don Birnam surrendering to the self-destructive nature of his addiction. Despite being good-looking and intelligent, Don is a hopeless alcoholic filled with self-loathing not. The brand doesn't matter, the cheaper the better – to him it's all the same. Drinking seems to be his only way to escape from his misery and low self-esteem. 

Yet, in one aspect he is lucky. Unlike many of his fellow sufferers he is not alone. After years of abuse, his faithful girlfriend Helen and his brother Wick have still not deserted him. Compassionately they do their utmost to protect Don from himself by keeping him under close observation. With great effort they determine the most inventive hiding-places of his bottles and they even visit nearby liquor stores and bars, begging not to accept Don as a customer. There is nothing they haven't tried, but Don appears to be beyond salvation. Just before the three of them are about to go on a weekend trip, Don devises a cunning plan to temporarily get rid of the two persons who care about him, giving him time to acquire the liquid he treasures the most. Soon he is stone drunk, staggering through the streets, always on the lookout for the next drink. For Don there will be no weekend trip. Only the bottle and the desperate humiliations connected with attaining it...